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    2017-3-2 · The X-ray diffraction data were collected under cryogenic conditions (100K) at Shanghai Synchrotron Radiation Facility (SSRF) beamline BL17U or BL19U1, and indexed, integrated, and scaled with HKL2000 (Otwinowski & …[1,2,4]Triazolo[1,5-a]pyrimidine derivative (Mol-5) is a ...2019-11-15 · [1,2,4]Triazolo[1,5-a]pyrimidine derivative (Mol-5) is a new NS5-RdRp inhibitor of DENV2 proliferation and DENV2-induced inflammation

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  • The crystal structure of Zika virus NS5 reveals conserved ...

    2017-3-2 · Recently, a novel broad‐spectrum inhibitor 12155 was identified by virtual screening (Brecher et al, 2015a). We compared the binding cavity of the 12155 with corresponding site in our ZIKV MTase structure and found that almost all residues involved in the interactions are conserved (Fig 7 B).The crystal structure of Zika virus NS5 reveals conserved ...2017-3-2 · The X-ray diffraction data were collected under cryogenic conditions (100K) at Shanghai Synchrotron Radiation Facility (SSRF) beamline BL17U or BL19U1, and indexed, integrated, and scaled with HKL2000 (Otwinowski & …

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  • The crystal structure of Zika virus NS5 reveals conserved ...

    2017-3-2 · Recently, a novel broad‐spectrum inhibitor 12155 was identified by virtual screening (Brecher et al, 2015a). We compared the binding cavity of the 12155 with corresponding site in our ZIKV MTase structure and found that almost all residues involved in the interactions are conserved (Fig 7 B).[1,2,4]Triazolo[1,5-a]pyrimidine derivative (Mol-5) is a ...2019-11-15 · Introduction. Dengue is a rapidly spreading vector-borne viral disease that is endemic in more than 100 countries [1–3].Approximately 54 million dengue fever cases were reported in Latin America and the Caribbean [].Mosquito-borne members of the Flavivirus family include four serotypes of dengue virus (DENV1–4), West Nile virus (WNV) and the recently …

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